S E Q U E G E N I C S
HLA Typing Solution
Accurate phased allele sequencing
HLA testing (also known as Tissue Typing; HLA Typing; Histocompatibility Testing; HLA Crossmatching) consists of determining the genetic identity of multiple genes located in the Human Leukocyte Antigen (HLA) region of the human genome. The HLA genes most frequently tested are HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DPB1 and HLA-DQB1. Because the HLA region is the most variable region of the human genome, both traditional and advanced DNA sequencing technologies struggle on determining the true identity of these genes. Because of these technical limitations, only limited segments of these genes (exons) are normally characterized, giving incomplete results in which each allele is reported as a group of potential alleles. For example, the HLA-A alleles in a particular patient might be characterized as “A*02:01:01G/A*11:01:01G”, meaning that the patient may harbor any of the 88 different A*02 alleles that are part of the A*02:01:01G group AND any of the 38 different A*11 alleles that are part of the A*11:01:01G group.